Anti-PBX1 Antibody

Rs. 45,619.00
SKU stj29704

General Information

Product name Anti-PBX1 Antibody
Short Description Rabbit polyclonal to PBX1
Description This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-PBX1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 311-430 of human PBX1 (NP_002576.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 46.6 kDa
Database Links
Alternative Names PBX1Pre-B-cell leukemia transcription factor 1 antibodyHomeobox protein PBX1 antibodyHomeobox protein PRLPBX1 antibodyPRL
Function Binds the sequence 5'-ATCAATCAA-3', Acts as a transcriptional activator of PF4 in complex with MEIS1, Converted into a potent transcriptional activator by the (1
Cellular Localization Nucleus
Tissue Specificity Expressed in the kidney, expressed in the endothelial cells of the glomeruli and interstitium (at protein level).
Swiss-Prot Key

 

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