Anti-PCMT1 Antibody

Rs. 45,619.00
SKU stj28767

General Information

Product name Anti-PCMT1 Antibody
Short Description Rabbit polyclonal to PCMT1
Description This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Applications WB,IF,IP
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
IP 1:50 - 1:200
Protein Name Anti-PCMT1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 62-286 of human PCMT1 (NP_001238978.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 24.6 kDa
Database Links
Alternative Names PCMT1Protein-L-isoaspartate(D-aspartate antibodyO-methyltransferase antibodyPIMTPCMT1
Function Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues, It plays a role in the repair and/or degradation of damaged proteins, Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein.
Cellular Localization Cytoplasm
Tissue Specificity
Swiss-Prot Key

 

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