Anti-PCSK9 Antibody

Rs. 61,689.00
SKU stj27802

General Information

Product name Anti-PCSK9 Antibody
Short Description Rabbit polyclonal to PCSK9
Description This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Applications WB,IHC,FC
Dilution range WB 1:500 - 1:1000
IHC 1:50 - 1:100
FC 1:20 - 1:50
Protein Name Anti-PCSK9 Antibody
Immunogen A synthetic peptide of human PCSK9
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 74.3 kDa
Database Links
Alternative Names PCSK9Proprotein convertase subtilisin/kexin type 9 PCSK9 antibodyNARC1 antibodyPSEC0052
Function Crucial player in the regulation of plasma cholesterol homeostasis, Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation, Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
Cellular Localization Cytoplasm, Secreted, Endosome, Lysosome, Cell surface, Endoplasmic reticulum, Golgi apparatus.
Tissue Specificity Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in schwann cells
Swiss-Prot Key

 

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