Anti-PCSK9 Antibody

Rs. 68,577.00
SKU stj71819

General Information

Product name Anti-PCSK9 Antibody
Short Description Goat polyclonal to PCSK9
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-PCSK9 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 74.3 kDa
Database Links
Alternative Names PCSK9Proprotein convertase subtilisin/kexin type 9 PCSK9 antibodyNARC1 antibodyPSEC0052
Function Crucial player in the regulation of plasma cholesterol homeostasis, Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation, Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways,
Cellular Localization Cytoplasm, Secreted, Endosome, Lysosome, Cell surface, Endoplasmic reticulum, Golgi apparatus,
Tissue Specificity Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in schwann cells
Swiss-Prot Key

 

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