Anti-PDCD4 Antibody

Rs. 45,619.00
SKU stj24925

General Information

Product name Anti-PDCD4 Antibody
Short Description Rabbit polyclonal to PDCD4
Description This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-PDCD4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PDCD4 (NP_055271.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 51.7 kDa
Database Links
Alternative Names PDCD4Programmed cell death protein 4 antibodyNeoplastic transformation inhibitor protein antibodyNuclear antigen H731-like antibodyProtein 197/15aPDCD4 antibodyH731
Function Inhibits translation initiation and cap-dependent translation, May excert its function by hindering the interaction between EIF4A1 and EIF4G, Inhibits the helicase activity of EIF4A, Modulates the activation of JUN kinase, Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription, May play a role in apoptosis, Tumor suppressor, Inhibits tumor promoter-induced neoplastic transformation, Binds RNA (By similarity).
Cellular Localization Nucleus.
Tissue Specificity Up-regulated in proliferative cells, highly expressed in epithelial cells of the mammary gland, reduced expression in lung cancer and colon carcinoma.
Swiss-Prot Key

 

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