Anti-PDK1 Antibody

Rs. 45,619.00
SKU stj24945

General Information

Product name Anti-PDK1 Antibody
Short Description Rabbit polyclonal to PDK1
Description Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-PDK1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PDK1 (NP_002601.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 49.2 kDa
Database Links
Alternative Names PDK1 kinase isozyme 1 antibodymitochondrial PDK1 antibodyPDHK1
Function Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2, This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate, Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia, Protects cells against apoptosis in response to hypoxia and oxidative stress.
Cellular Localization Mitochondrion matrix
Tissue Specificity Expressed predominantly in the heart, detected at lower levels in liver, skeletal muscle and pancreas.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed