Anti-PDK4 Antibody

Rs. 45,619.00
SKU stj24947

General Information

Product name Anti-PDK4 Antibody
Short Description Rabbit polyclonal to PDK4
Description This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:10 - 1:100
Protein Name Anti-PDK4 Antibody
Immunogen A synthetic peptide of human PDK4
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 46.5 kDa
Database Links
Alternative Names PDK4 kinase isozyme 4 antibodymitochondrial PDK4 antibodyPDHK4
Function Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2, This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate, Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation, Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade, Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation, In the fed state, mediates cellular responses to glucose levels and to a high-fat diet, Regulates both fatty acid oxidation and de novo fatty acid biosynthesis, Plays a role in the generation of reactive oxygen species, Protects detached epithelial cells against anoikis, Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
Cellular Localization Mitochondrion matrix
Tissue Specificity Ubiquitous
Swiss-Prot Key

 

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