Anti-PDX1 Antibody

Rs. 45,619.00
SKU stj24953

General Information

Product name Anti-PDX1 Antibody
Short Description Rabbit polyclonal to PDX1
Description The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-PDX1 Antibody
Immunogen A synthetic peptide of human PDX1
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 30.8 kDa
Database Links
Alternative Names PDX1Pancreas/duodenum homeobox protein 1 antibodyPDX-1 antibodyGlucose-sensitive factor antibodyGSF antibodyInsulin promoter factor 1 antibodyIPF-1 antibodyInsulin upstream factor 1 antibodyIUF-1 antibodyIslet/duodenum homeobox-1 antibodyIDX-1 antibodySomatostatin-transactivating factor 1 antibodySTF-1PDX1 antibodyIPF1 antibodySTF1
Function Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription, Particularly involved in glucose-dependent regulation of insulin gene transcription, As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer
Cellular Localization Nucleus, Cytoplasm, cytosol
Tissue Specificity Duodenum and pancreas (langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells)
Swiss-Prot Key

 

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