Anti-PDZK1 Antibody

Rs. 45,619.00
SKU stj27274

General Information

Product name Anti-PDZK1 Antibody
Short Description Rabbit polyclonal to PDZK1
Description This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-PDZK1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PDZK1 (NP_001188254.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 57.1 kDa
Database Links
Alternative Names PDZK1Na(+ antibody/H(+ antibodyexchange regulatory cofactor NHE-RF3 antibodyNHERF-3 antibodyCFTR-associated protein of 70 kDa antibodyNa(+ antibody/H(+ antibodyexchanger regulatory factor 3 antibodyNa/Pi cotransporter C-terminal-associated protein 1 antibodyNaPi-Cap1 antibodyPDZ domain-containing protein 1 antibodySodium-hydrogen exchanger regulatory factor 3PDZK1 antibodyCAP70 antibodyNHERF3 antibodyPDZD1
Function A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains, May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades, In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins, May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1, May potentiate the CFTR chloride channel activity, Required for normal cell-surface expression of SCARB1, Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1, Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney, May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
Cellular Localization Membrane
Tissue Specificity Expression is limited to epithelial cells, expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine, expressed at a lower level in the adrenal cortex, testis and stomach, overexpressed in breast, renal and lung carcinomas.
Swiss-Prot Key

 

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