Anti-PEG10 Antibody

Rs. 45,619.00
SKU stj24958

General Information

Product name Anti-PEG10 Antibody
Short Description Rabbit polyclonal to PEG10
Description This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene.
Applications WB
Dilution range WB 1:200 - 1:2000
Protein Name Anti-PEG10 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human PEG10 (NP_001035242.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 80.2 kDa
Database Links
Alternative Names PEG10Retrotransposon-derived protein PEG10 antibodyEmbryonal carcinoma differentiation-regulated protein antibodyMammalian retrotransposon-derived protein 2 antibodyMyelin expression factor 3-like protein 1 antibodyMEF3-like protein 1 antibodyPaternally expressed gene 10 protein antibodyRetrotransposon gag domain-containing protein 3 antibodyRetrotransposon-derived gag-like polyprotein antibodyTy3/Gypsy-like proteinPEG10 antibodyEDR antibodyKIAA1051 antibodyMAR2 antibodyMART2 antibodyMEF3L1 antibodyRGAG3
Function Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis, May also have a role in cell growth promotion and hepatoma formation, Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1, When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1, Involved at the immediate early stage of adipocyte differentiation (By similarity), May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity).
Cellular Localization Nucleus, Cytoplasm.
Tissue Specificity Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta, expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells, expressed in the hep-g2 cell line (at protein level), expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta, expressed in pancreatic and hepatocellular carcinomas (hcc).
Swiss-Prot Key

 

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