Anti-PEX5 Antibody

Rs. 45,619.00
SKU stj28347

General Information

Product name Anti-PEX5 Antibody
Short Description Rabbit polyclonal to PEX5
Description The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-PEX5 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PEX5 (NP_000310.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 70.9 kDa
Database Links
Alternative Names PEX5Peroxisomal targeting signal 1 receptor antibodyPTS1 receptor antibodyPTS1R antibodyPTS1-BP antibodyPeroxin-5 antibodyPeroxisomal C-terminal targeting signal import receptor antibodyPeroxisome receptor 1PEX5 antibodyPXR1
Function Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.
Cellular Localization Cytoplasm, Peroxisome membrane
Tissue Specificity Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Swiss-Prot Key

 

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