Anti-PGR Antibody

Rs. 45,619.00
SKU stj24976

General Information

Product name Anti-PGR Antibody
Short Description Rabbit polyclonal to PGR
Description This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-PGR Antibody
Immunogen A synthetic peptide of human PGR
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 99 kDa
Database Links
Alternative Names PGRProgesterone receptor antibodyPR antibodyNuclear receptor subfamily 3 group C member 3PGR antibodyNR3C3
Function The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues, Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.
Cellular Localization Nucleus, Cytoplasm, Mitochondrion outer membrane
Tissue Specificity In reproductive tissues the expression of isoform a and isoform b varies as a consequence of developmental and hormonal status, isoform a and isoform b are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle, expression of isoform b but not of isoform a persists in the glands during mid-secretory phase, in the stroma, isoform a is the predominant form throughout the cycle, heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region-specific responses to hormonal stimuli.
Swiss-Prot Key

 

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