Anti-PHF5A Antibody

Rs. 61,689.00
SKU stj24980

General Information

Product name Anti-PHF5A Antibody
Short Description Rabbit polyclonal to PHF5A
Description This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini. This protein belongs to the PHD-finger superfamily and may act as a chromatin-associated protein. This gene has several pseudogenes on different chromosomes.
Applications WB,FC
Dilution range WB 1:200 - 1:2000
FC 1:20 - 1:50
Protein Name Anti-PHF5A Antibody
Immunogen A synthetic peptide of human PHF5A
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 12.4 kDa
Database Links
Alternative Names PHF5APHD finger-like domain-containing protein 5A antibodyPHD finger-like domain protein 5A antibodySplicing factor 3B-associated 14 kDa protein antibodySF3b14bPHF5A
Function Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency, Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells, Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes, Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes, Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies, Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (By similarity), Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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