Anti-Phospho-20S Proteasome α3 (S250) antibody

Rs. 50,211.00
SKU stj90556

General Information

Product name Anti-Phospho-20S Proteasome α3 (S250) antibody
Short Description
Description Rabbit polyclonal to Phospho-20S Proteasome α3 (S250).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000
Protein Name Anti-Phospho-20S Proteasome α3 (S250) antibody
Immunogen Synthesized peptide derived from human 20S Proteasome α3 around the phosphorylation site of S250.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 32 kDa
Database Links
Alternative Names Phospho-20S Proteasome a3 (S250)
Proteasome subunit alpha type-3 antibody
Macropain subunit C8 antibody
Multicatalytic endopeptidase complex subunit C8 antibody
Proteasome component C8 antibody
HC8 antibody
PSC8 antibody
Function Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
Cellular Localization Cytoplasm Nucleus
Tissue Specificity
Swiss-Prot Key

 

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