Anti-Phospho-APC (S2054) antibody

Rs. 50,211.00
SKU stj90884

General Information

Product name Anti-Phospho-APC (S2054) antibody
Short Description
Description Rabbit polyclonal to Phospho-APC (S2054).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000
Protein Name Anti-Phospho-APC (S2054) antibody
Immunogen Synthesized peptide derived from human APC around the phosphorylation site of S2054.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 311 kDa
Database Links
Alternative Names Phospho-APC (S2054)
Adenomatous polyposis coli protein antibody
Protein APC antibody
Deleted in polyposis 2.5 antibody
DP2.5 antibody
Function Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Cellular Localization Cell junction, adherens junction Cytoplasm, cytoskeleton Cell projection, lamellipodium Cell projection, ruffle membrane Cytoplasm Cell membrane. Associated with the microtubule network at the growing distal tip of microtubules . Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment . The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane .
Tissue Specificity Expressed in a variety of tissues.
Swiss-Prot Key

 

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