Anti-Phospho-ASK 1 (S966) antibody

Rs. 50,211.00
SKU stj90182

General Information

Product name Anti-Phospho-ASK 1 (S966) antibody
Short Description
Description Rabbit polyclonal to Phospho-ASK 1 (S966).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000
Protein Name Anti-Phospho-ASK 1 (S966) antibody
Immunogen Synthesized peptide derived from human ASK 1 around the phosphorylation site of S966.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 155 kDa
Database Links
Alternative Names Phospho-ASK 1 (S966)
Mitogen-activated protein kinase kinase kinase 5 antibody
Apoptosis signal-regulating kinase 1 antibody
ASK-1 antibody
MAPK/ERK kinase kinase 5 antibody
MEK kinase 5 antibody
MEKK 5 antibody
ASK1 antibody
MAPKKK5 antibody
MEKK5 antibody
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
Cellular Localization Cytoplasm. Endoplasmic reticulum. Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.
Tissue Specificity Abundantly expressed in heart and pancreas.
Swiss-Prot Key

 

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