Anti-Phospho-BCR-(Y177) Antibody

Rs. 50,211.00
SKU stj29372

General Information

Product name Anti-Phospho-BCR-(Y177) Antibody
Short Description Rabbit Polyclonal to PhosphoBCR(Y177)
Description A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-Phospho-BCR-(Y177) Antibody
Immunogen A phospho specific peptide corresponding to residues surrounding Y177 of human BCR
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 142.8 kDa
Database Links
Alternative Names BCRBreakpoint cluster region protein BCR antibodyBCR1 antibodyD22S11
Function GTPase-activating protein for RAC1 and CDC42, Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them, Displays serine/threonine kinase activity.
Cellular Localization Cell junction, synapse, postsynaptic cell membrane, postsynaptic density
Tissue Specificity
Swiss-Prot Key

 

You recently viewed

Clear recently viewed