Anti-Phospho-Bim (S59) antibody

Rs. 50,211.00
SKU stj91225

General Information

Product name Anti-Phospho-Bim (S59) antibody
Short Description Rabbit polyclonal to Phospho-Bim (S59).
Description Bim is a protein encoded by the BCL2L11 gene which is approximately 22,1 kDa. Bim is localised to the mitochondrion. It is involved in the activation of BH3-only proteins, apoptosis modulation and signalling, p75 NTR receptor-mediated signalling and MAPK signalling. It forms a hetero- or homodimers and acts as anti- or pro-apoptotic regulator that is involved in a wide variety of cellular activities. Bim isoform gamma is most abundantly expressed in small intestine and colon. Other isoforms are widely expressed with tissue-specific variation. Mutations in the BCL2L11 gene may result in ocular hyperemia and autoimmune lymphoproliferative syndrome. stj91225 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Bim protein which only binds about S59 when S59 is phosphorylated.
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:40000
Protein Name Anti-Phospho-Bim (S59) antibody
Immunogen Synthesized peptide derived from human Bim around the phosphorylation site of S59.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 25/22 kDa
Database Links
Alternative Names Phospho-Bim (S59)
Bcl-2-like protein 11 antibody
Bcl2-L-11 antibody
Bcl2-interacting mediator of cell death antibody
BIM antibody
Function Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Cellular Localization Endomembrane system. Associated with intracytoplasmic membranes. Isoform BimEL: Mitochondrion. Translocates from microtubules to motochondria on loss of cell adherence.. Isoform BimL: Mitochondrion.. Isoform BimS: Mitochondrion.. Isoform Bim-alpha1: Mitochondrion.
Tissue Specificity Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
Swiss-Prot Key

 

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