Anti-Phospho-BLNK (Y96) antibody

Rs. 50,211.00
SKU stj90847

General Information

Product name Anti-Phospho-BLNK (Y96) antibody
Short Description
Description Rabbit polyclonal to Phospho-BLNK (Y96).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000
Protein Name Anti-Phospho-BLNK (Y96) antibody
Immunogen Synthesized peptide derived from human BLNK around the phosphorylation site of Y96.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Monkey
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 50 kDa
Database Links
Alternative Names Phospho-BLNK (Y96)
B-cell linker protein antibody
B-cell adapter containing a SH2 domain protein antibody
B-cell adapter containing a Src homology 2 domain protein antibody
Cytoplasmic adapter protein antibody
Src homology 2 domain-containing leukocyte protein of 65 kDa antibody
SLP-65 antibody
BASH antibody
SLP65 antibody
Function Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Cellular Localization Cytoplasm Cell membrane. BCR activation results in the translocation to membrane fraction.
Tissue Specificity Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
Swiss-Prot Key

 

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