General Information
| Product name | Anti-Phospho-c-Fos (S32) antibody |
|---|---|
| Short Description | |
| Description | Rabbit polyclonal to Phospho-c-Fos (S32). |
| Applications | WB,ELISA |
| Dilution range | WB 1:500-1:2000ELISA 1:5000 |
| Protein Name | Anti-Phospho-c-Fos (S32) antibody |
| Immunogen | Synthesized peptide derived from human c-Fos around the phosphorylation site of S32. |
| Storage Instruction | Store at -20°C, and avoid repeat freeze-thaw cycles. |
| Type of Usage | For Research Use Only (RUO). |
Product Properties
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Reactivity | Mouse,Rat |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Isotype | IgG |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Target
| Gene ID | |
|---|---|
| Gene Symbol | |
| Molecular Weight | 45 kDa |
| Database Links | |
| Alternative Names | Phospho-c-Fos (S32) Proto-oncogene c-Fos antibody Cellular oncogene fos antibody G0/G1 switch regulatory protein 7 antibody G0S7 antibody |
| Function | Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. |
| Cellular Localization | Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30. |
| Tissue Specificity | |
| Swiss-Prot Key |