Anti-Phospho-CCND1-(T286) Antibody

Rs. 50,211.00
SKU stj29340

General Information

Product name Anti-Phospho-CCND1-(T286) Antibody
Short Description Rabbit Polyclonal to PhosphoCCND1(T286)
Description The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-Phospho-CCND1-(T286) Antibody
Immunogen A phospho specific peptide corresponding to residues surrounding T286 of human CCND1
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 33.7 kDa
Database Links
Alternative Names CCND1G1/S-specific cyclin-D1 antibodyB-cell lymphoma 1 protein antibodyBCL-1 antibodyBCL-1 oncogene antibodyPRAD1 oncogeneCCND1 antibodyBCL1 antibodyPRAD1
Function Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition, Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase, Hypophosphorylates RB1 in early G(1) phase, Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals, Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity, Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex, Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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