Anti-Phospho-cGKII (S126) antibody

Rs. 50,211.00
SKU stj91216

General Information

Product name Anti-Phospho-cGKII (S126) antibody
Short Description
Description Rabbit polyclonal to Phospho-cGKII (S126).
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:5000
Protein Name Anti-Phospho-cGKII (S126) antibody
Immunogen Synthesized peptide derived from human cGKII around the phosphorylation site of S126.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 87 kDa
Database Links
Alternative Names Phospho-cGKII (S126)
cGMP-dependent protein kinase 2 antibody
cGK 2 antibody
cGK2 antibody
cGMP-dependent protein kinase II antibody
cGKII antibody
PRKGR2 antibody
Function Crucial regulator of intestinal secretion and bone growth . Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum . Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 . Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation .
Cellular Localization Apical cell membrane
Tissue Specificity Highly concentrated in brain, lung and intestinal mucosa.
Swiss-Prot Key

 

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