Anti-Phospho-Cofilin (S3) antibody

Rs. 50,211.00
SKU stj90230

General Information

Product name Anti-Phospho-Cofilin (S3) antibody
Short Description Rabbit polyclonal to Phospho-Cofilin (S3).
Description Cofilin is a protein encoded by the JAK1 gene which is approximately 133,2 kDa. Cofilin is localised to the endomembrane system and is involved in RET signalling, common cytokine receptor gamma-chain family signalling pathways, Th17 cell differentiation and IL27-mediated signalling events. It phosphorylates STAT proteins and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Cofilin is expressed at higher levels in primary colon tumor than normal colon tissue. Mutations in the JAK1 gene may result in mixed lacrimal gland cancer, t-cell prolymphocytic leukemia and chilblain lupus. The antibody stj90230 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Cofilin protein which only binds about S3 when S3 is phosphorylated.
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000
Protein Name Anti-Phospho-Cofilin (S3) antibody
Immunogen Synthesized peptide derived from human Cofilin around the phosphorylation site of S3.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 19 kDa
Database Links
Alternative Names Phospho-Cofilin (S3)
Cofilin-1 antibody
18 kDa phosphoprotein antibody
p18 antibody
Cofilin, non-muscle isoform antibodyA antibodyB antibody
Function Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway . Kinase partner for the interleukin (IL)-2 receptor .
Cellular Localization Endomembrane system. Peripheral membrane protein. Wholly intracellular, possibly membrane associated.
Tissue Specificity Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
Swiss-Prot Key

 

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