Anti-Phospho-Csk (S364) antibody

Rs. 50,211.00
SKU stj90456

General Information

Product name Anti-Phospho-Csk (S364) antibody
Short Description
Description Rabbit polyclonal to Phospho-Csk (S364).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000
Protein Name Anti-Phospho-Csk (S364) antibody
Immunogen Synthesized peptide derived from human Csk around the phosphorylation site of S364.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 50 kDa
Database Links
Alternative Names Phospho-Csk (S364)
Tyrosine-protein kinase CSK antibody
C-Src kinase antibody
Protein-tyrosine kinase CYL antibody
Function Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Cellular Localization Cytoplasm Cell membrane. Mainly cytoplasmic, also present in lipid rafts.
Tissue Specificity Expressed in lung and macrophages.
Swiss-Prot Key

 

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