Anti-Phospho-Doublecortin (S339) antibody

Rs. 50,211.00
SKU stj91251

General Information

Product name Anti-Phospho-Doublecortin (S339) antibody
Short Description
Description Rabbit polyclonal to Phospho-Doublecortin (S339).
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:5000
Protein Name Anti-Phospho-Doublecortin (S339) antibody
Immunogen Synthesized peptide derived from human Doublecortin around the phosphorylation site of S376.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 38 kDa
Database Links
Alternative Names Phospho-Doublecortin (S339)
Neuronal migration protein doublecortin antibody
Doublin antibody
Lissencephalin-X antibody
Lis-X antibody
DBCN antibody
LISX antibody
Function Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
Cellular Localization Cytoplasm Cell projection. Localizes at neurite tips.
Tissue Specificity Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.
Swiss-Prot Key

 

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