Anti-Phospho-DREAM (S63) antibody

Rs. 50,211.00
SKU stj91090

General Information

Product name Anti-Phospho-DREAM (S63) antibody
Short Description
Description Rabbit polyclonal to Phospho-DREAM (S63).
Applications WB,IHC,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000
Protein Name Anti-Phospho-DREAM (S63) antibody
Immunogen Synthesized peptide derived from human DREAM around the phosphorylation site of S63.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 29 kDa
Database Links
Alternative Names Phospho-DREAM (S63)
Calsenilin antibody
A-type potassium channel modulatory protein 3 antibody
DRE-antagonist modulator antibody
DREAM antibody
Kv channel-interacting protein 3 antibody
KChIP3 antibody
CSEN antibody
DREAM antibody
KCHIP3 antibody
Function Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception . Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.
Cellular Localization Cytoplasm Cell membrane Endoplasmic reticulum Golgi apparatus Nucleus. Also membrane-bound, associated with the plasma membrane . In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus.
Tissue Specificity Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.
Swiss-Prot Key

 

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