Anti-Phospho-Emt (Y512) antibody

Rs. 50,211.00
SKU stj91164

General Information

Product name Anti-Phospho-Emt (Y512) antibody
Short Description
Description Rabbit polyclonal to Phospho-Emt (Y512).
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:5000
Protein Name Anti-Phospho-Emt (Y512) antibody
Immunogen Synthesized peptide derived from human Emt around the phosphorylation site of Y512.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 72 kDa
Database Links
Alternative Names Phospho-Emt (Y512)
Tyrosine-protein kinase ITK/TSK antibody
Interleukin-2-inducible T-cell kinase antibody
IL-2-inducible T-cell kinase antibody
Kinase EMT antibody
T-cell-specific kinase antibody
Tyrosine-protein kinase Lyk antibody
EMT antibody
LYK antibody
Function Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.
Cellular Localization Cytoplasm. Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation.
Tissue Specificity T-cell lines and natural killer cell lines.
Swiss-Prot Key

 

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