Anti-Phospho-EphA7 (Y791) antibody

Rs. 50,211.00
SKU stj90668

General Information

Product name Anti-Phospho-EphA7 (Y791) antibody
Short Description
Description Rabbit polyclonal to Phospho-EphA7 (Y791).
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:10000
Protein Name Anti-Phospho-EphA7 (Y791) antibody
Immunogen Synthesized peptide derived from human EphA7 around the phosphorylation site of Y791.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 112 kDa
Database Links
Alternative Names Phospho-EphA7 (Y791)
Ephrin type-A receptor 7 antibody
EPH homology kinase 3 antibody
EHK-3 antibody
EPH-like kinase 11 antibody
EK11 antibody
hEK11 antibody
EHK3 antibody
HEK11 antibody
Function Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
Cellular Localization Cell membrane
Tissue Specificity Widely expressed.
Swiss-Prot Key

 

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