Anti-Phospho-Flt-1 (Y1213) antibody

Rs. 50,211.00
SKU stj91359

General Information

Product name Anti-Phospho-Flt-1 (Y1213) antibody
Short Description
Description Rabbit polyclonal to Phospho-Flt-1 (Y1213).
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:40000
Protein Name Anti-Phospho-Flt-1 (Y1213) antibody
Immunogen Synthesized peptide derived from human Flt-1 around the phosphorylation site of Y1213.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 180 kDa
Database Links
Alternative Names Phospho-Flt-1 (Y1213)
Vascular endothelial growth factor receptor 1 antibody
VEGFR-1 antibody
Fms-like tyrosine kinase 1 antibody
FLT-1 antibody
Tyrosine-protein kinase FRT antibody
Tyrosine-protein kinase receptor FLT antibody
FLT antibody
Vascular permeability factor receptor antibody
FLT antibody
FRT antibody
VEGFR1 antibody
Function Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.
Cellular Localization Isoform 1: Cell membrane. Single-pass type I membrane protein. Endosome. Autophosphorylation promotes ubiquitination and endocytosis.. Isoform 2: Secreted Isoform 3: Secreted.. Isoform 4: Secreted.. Isoform 5: Cytoplasm Isoform 6: Cytoplasm Isoform 7: Cytoplasm
Tissue Specificity Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC).
Swiss-Prot Key

 

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