Anti-Phospho-Flt-3 (Y969) antibody

Rs. 50,211.00
SKU stj90944

General Information

Product name Anti-Phospho-Flt-3 (Y969) antibody
Short Description
Description Rabbit polyclonal to Phospho-Flt-3 (Y969).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000
Protein Name Anti-Phospho-Flt-3 (Y969) antibody
Immunogen Synthesized peptide derived from human Flt-3 around the phosphorylation site of Y969.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 150/120 kDa
Database Links
Alternative Names Phospho-Flt-3 (Y969)
Receptor-type tyrosine-protein kinase FLT3 antibody
FL cytokine receptor antibody
Fetal liver kinase-2 antibody
FLK-2 antibody
Fms-like tyrosine kinase 3 antibody
FLT-3 antibody
Stem cell tyrosine kinase 1 antibody
STK-1 antibody
CD antigen CD135 antibody
CD135 antibody
FLK2 antibody
STK1 antibody
Function Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Cellular Localization Membrane. Single-pass type I membrane protein. Endoplasmic reticulum lumen. Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.
Tissue Specificity Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia.
Swiss-Prot Key

 

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