Anti-Phospho-FoxO3A (S253) antibody

Rs. 50,211.00
SKU stj90275

General Information

Product name Anti-Phospho-FoxO3A (S253) antibody
Short Description Rabbit polyclonal to Phospho-FoxO3A (S253).
Description FoxO3A is a protein encoded by the FOXO3 gene which is approximately 71,2 kDa. FoxO3A is localised to the cytoplasm and nucleus. It is involved in RET signalling, GAB1 signalosome, glioma and common cytokine receptor gamma-chain family signalling pathways. It is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It also participates in post-transcriptional regulation of MYC. FoxO3A is expressed ubiquitously. Mutations in the FOXO3 gene may result in secondary acute leukemia. stj90275 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous FoxO3A protein which only binds about S253 when S253 is phosphorylated.
Applications WB,IHC,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000
Protein Name Anti-Phospho-FoxO3A (S253) antibody
Immunogen Synthesized peptide derived from human FoxO3A around the phosphorylation site of S253.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 71 kDa
Database Links
Alternative Names Phospho-FoxO3A (S253)
Forkhead box protein O3 antibody
AF6q21 protein antibody
Forkhead in rhabdomyosarcoma-like 1 antibody
FKHRL1 antibodyA antibody
Function Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Cellular Localization Cytoplasm, cytosol Nucleus. Retention in the cytoplasm contributes to its inactivation. Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
Tissue Specificity Ubiquitous.
Swiss-Prot Key

 

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