Anti-Phospho-Girdin (S1417) antibody

Rs. 50,211.00
SKU stj91256

General Information

Product name Anti-Phospho-Girdin (S1417) antibody
Short Description
Description Rabbit polyclonal to Phospho-Girdin (S1417).
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:5000
Protein Name Anti-Phospho-Girdin (S1417) antibody
Immunogen Synthesized peptide derived from human Girdin around the phosphorylation site of S1417.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 216.042 kDa
Database Links
Alternative Names Phospho-Girdin (S1417)
Girdin antibody
Akt phosphorylation enhancer antibody
APE antibody
Coiled-coil domain-containing protein 88A antibody
G alpha-interacting vesicle-associated protein antibody
GIV antibody
Girders of actin filament antibody
Hook-related protein 1 antibody
HkRP1 antibody
APE antibody
GRDN antibody
KIAA1212 antibody
Function Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation . Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself . Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation . Essential for the integrity of the actin cytoskeleton and for cell migration . Required for formation of actin stress fibers and lamellipodia . May be involved in membrane sorting in the early endosome . Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin .
Cellular Localization Membrane Cell membrane Cytoplasm, cytosol Cytoplasmic vesicle Cell projection, lamellipodium Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Localizes to the cell membrane through interaction with phosphoinositides.
Tissue Specificity Expressed ubiquitously.
Swiss-Prot Key

 

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