Anti-Phospho-GSK3A-(S21) Antibody

Rs. 50,211.00
SKU stj29348

General Information

Product name Anti-Phospho-GSK3A-(S21) Antibody
Short Description Rabbit polyclonal to PhosphoGSK3A(S21)
Description This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease.
Applications WB,IHC,IP
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IP 1:50 - 1:100
Protein Name Anti-Phospho-GSK3A-(S21) Antibody
Immunogen A phospho specific peptide corresponding to residues surrounding S21 of human GSK3A
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 51 kDa
Database Links
Alternative Names GSK3AGlycogen synthase kinase-3 alpha antibodyGSK-3 alphaGSK3A
Function Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1, Requires primed phosphorylation of the majority of its substrates, Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis, Regulates glycogen metabolism in liver, but not in muscle, May also mediate the development of insulin resistance by regulating activation of transcription factors, In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin, Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease, May be involved in the regulation of replication in pancreatic beta-cells, Is necessary for the establishment of neuronal polarity and axon outgrowth, Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
Cellular Localization
Tissue Specificity
Swiss-Prot Key

 

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