Anti-Phospho-Hck (Y410) antibody

Rs. 50,211.00
SKU stj91341

General Information

Product name Anti-Phospho-Hck (Y410) antibody
Short Description
Description Rabbit polyclonal to Phospho-Hck (Y410).
Applications IHC,IF,ELISA
Dilution range IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000
Protein Name Anti-Phospho-Hck (Y410) antibody
Immunogen Synthesized peptide derived from human Hck around the phosphorylation site of Y410.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 61 kDa
Database Links
Alternative Names Phospho-Hck (Y410)
Tyrosine-protein kinase HCK antibody
Hematopoietic cell kinase antibody
Hemopoietic cell kinase antibody
p59-HCK/p60-HCK antibody
p59Hck antibody
p61Hck antibody
Function Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
Cellular Localization Isoform 1: Lysosome. Membrane. Lipid-anchor. Cell projection, podosome membrane. Lipid-anchor. Cytoplasm, cytosol. Associated with specialized secretory lysosomes called azurophil granules. At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated.. Isoform 2: Cell membrane Membrane, caveola Cell junction, focal adhesion Cytoplasm, cytoskeleton Golgi apparatus Cytoplasmic vesicle Lysosome Nucleus. 20% of this isoform is associated with caveolae. Localization at the cell membrane and at caveolae requires palmitoylation at Cys-3. Colocalizes with the actin cytoskeleton at focal adhesions.. Cytoplasmic vesicle, secretory vesicle. Cytoplasm, cytosol.
Tissue Specificity Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil.
Swiss-Prot Key

 

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