Anti-Phospho-HDAC3 (S424) antibody

Rs. 50,211.00
SKU stj91081

General Information

Product name Anti-Phospho-HDAC3 (S424) antibody
Short Description
Description Rabbit polyclonal to Phospho-HDAC3 (S424).
Applications WB,IHC,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000
Protein Name Anti-Phospho-HDAC3 (S424) antibody
Immunogen Synthesized peptide derived from human HDAC3 around the phosphorylation site of S424.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 48 kDa
Database Links
Alternative Names Phospho-HDAC3 (S424)
Histone deacetylase 3 antibody
HD3 antibody
RPD3-2 antibody
SMAP45 antibody
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation . Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress .
Cellular Localization Nucleus Cytoplasm Cytoplasm, cytosol. Colocalizes with XBP1 and AKT1 in the cytoplasm . Predominantly expressed in the nucleus in the presence of CCAR2.
Tissue Specificity Widely expressed.
Swiss-Prot Key

 

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