Anti-Phospho-HDAC5/9 (S259/220) antibody

Rs. 50,211.00
SKU stj90459

General Information

Product name Anti-Phospho-HDAC5/9 (S259/220) antibody
Short Description
Description Rabbit polyclonal to Phospho-HDAC5/9 (S259/220).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000
Protein Name Anti-Phospho-HDAC5/9 (S259/220) antibody
Immunogen Synthesized peptide derived from human HDAC5/9 around the phosphorylation site of S259/220.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 121 kDa
Database Links
Alternative Names Phospho-HDAC5/9 (S259/220)
Histone deacetylase 5 antibody
HD5 antibody
Antigen NY-CO-9 antibody
KIAA0600 antibody
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Cellular Localization Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.
Tissue Specificity Ubiquitous.
Swiss-Prot Key

 

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