Anti-Phospho-hnRNP K (S284) antibody

Rs. 50,211.00
SKU stj90527

General Information

Product name Anti-Phospho-hnRNP K (S284) antibody
Short Description
Description Rabbit polyclonal to Phospho-hnRNP K (S284).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000
Protein Name Anti-Phospho-hnRNP K (S284) antibody
Immunogen Synthesized peptide derived from human hnRNP K around the phosphorylation site of S284.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat,Monkey
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 51 kDa
Database Links
Alternative Names Phospho-hnRNP K (S284)
Heterogeneous nuclear ribonucleoprotein K antibody
hnRNP K antibody
Transformation up-regulated nuclear protein antibody
TUNP antibody
HNRPK antibody
Function One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction . As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
Cellular Localization Cytoplasm Nucleus, nucleoplasm Cell projection, podosome. Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53 . In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear .
Tissue Specificity
Swiss-Prot Key

 

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