Anti-Phospho-HtrA2 (S212) antibody

Rs. 50,211.00
SKU stj91257

General Information

Product name Anti-Phospho-HtrA2 (S212) antibody
Short Description
Description Rabbit polyclonal to Phospho-HtrA2 (S212).
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:40000
Protein Name Anti-Phospho-HtrA2 (S212) antibody
Immunogen Synthesized peptide derived from human HtrA2 around the phosphorylation site of S212.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 45-50 kDa
Database Links
Alternative Names Phospho-HtrA2 (S212)
Serine protease HTRA2, mitochondrial antibody
High temperature requirement protein A2 antibody
HtrA2 antibody
Omi stress-regulated endoprotease antibody
Serine protease 25 antibody
Serine proteinase OMI antibody
OMI antibody
PRSS25 antibody
Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Cellular Localization Mitochondrion intermembrane space. Mitochondrion membrane. Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
Tissue Specificity Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
Swiss-Prot Key

 

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