Anti-Phospho-IKKγ (S31) antibody

Rs. 50,211.00
SKU stj90798

General Information

Product name Anti-Phospho-IKKγ (S31) antibody
Short Description
Description Rabbit polyclonal to Phospho-IKKγ (S31).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000
Protein Name Anti-Phospho-IKKγ (S31) antibody
Immunogen Synthesized peptide derived from human IKKγ around the phosphorylation site of S31.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 48 kDa
Database Links
Alternative Names Phospho-IKK (S31)
NF-kappa-B essential modulator antibody
NEMO antibody
FIP-3 antibody
IkB kinase-associated protein 1 antibody
IKKAP1 antibody
Inhibitor of nuclear factor kappa-B kinase subunit gamma antibody
I-kappa-B kinase subunit gamma antibody
IKK-gamma antibody
IKKG antibody
IkB kinase subunit gamma antibody
NF-kappa-B essential modifier antibody
FIP3 antibody
NEMO antibody
Function Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
Cellular Localization Cytoplasm Nucleus. Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress.
Tissue Specificity Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Swiss-Prot Key

 

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