Anti-Phospho-Integrin α4 (S1027) antibody

Rs. 50,211.00
SKU stj91315

General Information

Product name Anti-Phospho-Integrin α4 (S1027) antibody
Short Description
Description Rabbit polyclonal to Phospho-Integrin α4 (S1027).
Applications IHC,IF,ELISA
Dilution range IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000
Protein Name Anti-Phospho-Integrin α4 (S1027) antibody
Immunogen Synthesized peptide derived from human Integrin α4 around the phosphorylation site of S1027.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 120 kDa
Database Links
Alternative Names Phospho-Integrin a4 (S1027)
Integrin alpha-4 antibody
CD49 antigen-like family member D antibody
Integrin alpha-IV antibody
VLA-4 subunit alpha antibody
CD antigen CD49d antibody
CD49D antibody
Function Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling . ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 .
Cellular Localization Membrane. Single-pass type I membrane protein.
Tissue Specificity
Swiss-Prot Key

 

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