Anti-Phospho-Intestinal Cell Kinase (Y159) antibody

Rs. 50,211.00
SKU stj90581

General Information

Product name Anti-Phospho-Intestinal Cell Kinase (Y159) antibody
Short Description
Description Rabbit polyclonal to Phospho-Intestinal Cell Kinase (Y159).
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:10000
Protein Name Anti-Phospho-Intestinal Cell Kinase (Y159) antibody
Immunogen Synthesized peptide derived from human Intestinal Cell Kinase around the phosphorylation site of Y159.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 71 kDa
Database Links
Alternative Names Phospho-Intestinal Cell Kinase (Y159)
Serine/threonine-protein kinase ICK antibody
Intestinal cell kinase antibody
hICK antibody
Laryngeal cancer kinase 2 antibody
LCK2 antibody
MAK-related kinase antibody
MRK antibody
KIAA0936 antibody
Function Required for ciliogenesis . Phosphorylates KIF3A . Involved in the control of ciliary length . Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips . May play a key role in the development of multiple organ systems and particularly in cardiac development . Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity .
Cellular Localization Nucleus Cytoplasm, cytosol Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body. Also found at the ciliary tip . Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells .
Tissue Specificity Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines.
Swiss-Prot Key

 

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