Anti-Phospho-KDR-(Y996) Antibody

Rs. 50,211.00
SKU stj29361

General Information

Product name Anti-Phospho-KDR-(Y996) Antibody
Short Description Rabbit Polyclonal to PhosphoKDR(Y996)
Description Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-Phospho-KDR-(Y996) Antibody
Immunogen A phospho specific peptide corresponding to residues surrounding Y996 of human VEGFR2
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 151.5 kDa
Database Links
Alternative Names KDRVascular endothelial growth factor receptor 2 antibodyVEGFR-2KDR antibodyFLK1 antibodyVEGFR2
Function Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD, Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis, Promotes proliferation, survival, migration and differentiation of endothelial cells, Promotes reorganization of the actin cytoskeleton, Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD, Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4, Modulates FLT1 and FLT4 signaling by forming heterodimers, Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades, Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C, Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway, Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1, Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells, Phosphorylates PLCG1, Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.
Cellular Localization Cell junction, Secreted
Tissue Specificity Detected in cornea (at protein level), widely expressed.
Swiss-Prot Key

 

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