Anti-Phospho-KIF2C (S95) antibody

Rs. 50,211.00
SKU stj90726

General Information

Product name Anti-Phospho-KIF2C (S95) antibody
Short Description
Description Rabbit polyclonal to Phospho-KIF2C (S95).
Applications WB,IF,ELISA
Dilution range WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000
Protein Name Anti-Phospho-KIF2C (S95) antibody
Immunogen Synthesized peptide derived from human KIF2C around the phosphorylation site of S95.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 80 kDa
Database Links
Alternative Names Phospho-KIF2C (S95)
Kinesin-like protein KIF2C antibody
Kinesin-like protein 6 antibody
Mitotic centromere-associated kinesin antibody
MCAK antibody
KNSL6 antibody
Function In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells . Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis . Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment .
Cellular Localization Cytoplasm, cytoskeleton Nucleus Chromosome, centromere Chromosome, centromere, kinetochore. Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 . Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2.
Tissue Specificity Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.
Swiss-Prot Key

 

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