Anti-Phospho-LATS1/2 (T1079/1041) antibody

Rs. 50,211.00
SKU stj91207

General Information

Product name Anti-Phospho-LATS1/2 (T1079/1041) antibody
Short Description
Description Rabbit polyclonal to Phospho-LATS1/2 (T1079/1041).
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:20000
Protein Name Anti-Phospho-LATS1/2 (T1079/1041) antibody
Immunogen Synthesized peptide derived from human LATS1/2 around the phosphorylation site of T1079/1041.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 130 kDa
Database Links
Alternative Names Phospho-LATS1/2 (T1079/1041)
Serine/threonine-protein kinase LATS1 antibody
Large tumor suppressor homolog 1 antibody
WARTS protein kinase antibody
h-warts antibody
WARTS antibody
Function Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 .
Cellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.
Tissue Specificity Expressed in all adult tissues examined except for lung and kidney.
Swiss-Prot Key

 

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