Anti-Phospho-MAPKAPK2-(T334) Antibody

Rs. 50,211.00
SKU stj29354

General Information

Product name Anti-Phospho-MAPKAPK2-(T334) Antibody
Short Description Rabbit Polyclonal to PhosphoMAPKAPK2(T334)
Description This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-Phospho-MAPKAPK2-(T334) Antibody
Immunogen A phospho specific peptide corresponding to residues surrounding T334 of human MAPKAPK2
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 45.6 kDa
Database Links
Alternative Names MAPKAPK2MAP kinase-activated protein kinase 2 antibodyMAPK-activated protein kinase 2 antibodyMAPKAP kinase 2 antibodyMAPKAP-K2 antibodyMAPKAPK-2 antibodyMK-2 antibodyMK2MAPKAPK2
Function Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation, Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates, Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue, Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36, Phosphorylates HSF1
Cellular Localization Cytoplasm.
Tissue Specificity Expressed in all tissues examined
Swiss-Prot Key

 

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