Anti-Phospho-MARK1/2/3/4 (T215) antibody

Rs. 50,211.00
SKU stj91168

General Information

Product name Anti-Phospho-MARK1/2/3/4 (T215) antibody
Short Description
Description Rabbit polyclonal to Phospho-MARK1/2/3/4 (T215).
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:5000
Protein Name Anti-Phospho-MARK1/2/3/4 (T215) antibody
Immunogen Synthesized peptide derived from human MARK1/2/3/4 around the phosphorylation site of T215.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 89 kDa
Database Links
Alternative Names Phospho-MARK1/2/3/4 (T215)
Serine/threonine-protein kinase MARK1 antibody
MAP/microtubule affinity-regulating kinase 1 antibody
PAR1 homolog c antibody
Par-1c antibody
Par1c antibody
KIAA1477 antibody
MARK antibody
Function Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Cellular Localization Cell membrane Cytoplasm, cytoskeleton. Appears to localize to an intracellular network.
Tissue Specificity Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.
Swiss-Prot Key

 

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