Anti-Phospho-MEK-6 (S207) antibody

Rs. 50,211.00
SKU stj90333

General Information

Product name Anti-Phospho-MEK-6 (S207) antibody
Short Description
Description Rabbit polyclonal to Phospho-MEK-6 (S207).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000
Protein Name Anti-Phospho-MEK-6 (S207) antibody
Immunogen Synthesized peptide derived from human MEK-6 around the phosphorylation site of S207.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 39 kDa
Database Links
Alternative Names Phospho-MEK-6 (S207)
Dual specificity mitogen-activated protein kinase kinase 6 antibody
MAP kinase kinase 6 antibody
MAPKK 6 antibody
MAPK/ERK kinase 6 antibody
MEK 6 antibody
Stress-activated protein kinase kinase 3 antibody
SAPK kinase 3 antibody
SAPKK-3 antibody
SAPKK3 antibody
MEK6 antibody
MKK6 antibody
PRKMK6 antibody
SKK3 antibody
Function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
Cellular Localization Nucleus Cytoplasm Cytoplasm, cytoskeleton. Binds to microtubules.
Tissue Specificity Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas.
Swiss-Prot Key

 

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