Anti-Phospho-MLK3 (S674) antibody

Rs. 50,211.00
SKU stj91362

General Information

Product name Anti-Phospho-MLK3 (S674) antibody
Short Description
Description Rabbit polyclonal to Phospho-MLK3 (S674).
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:5000
Protein Name Anti-Phospho-MLK3 (S674) antibody
Immunogen Synthesized peptide derived from human MLK3 around the phosphorylation site of S674.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 92 kDa
Database Links
Alternative Names Phospho-MLK3 (S674)
Mitogen-activated protein kinase kinase kinase 11 antibody
Mixed lineage kinase 3 antibody
Src-homology 3 domain-containing proline-rich kinase antibody
MLK3 antibody
PTK1 antibody
SPRK antibody
Function Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
Cellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Location is cell cycle dependent.
Tissue Specificity Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.
Swiss-Prot Key

 

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