Anti-Phospho-MSK2 (T568) antibody

Rs. 50,211.00
SKU stj90952

General Information

Product name Anti-Phospho-MSK2 (T568) antibody
Short Description
Description Rabbit polyclonal to Phospho-MSK2 (T568).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000
Protein Name Anti-Phospho-MSK2 (T568) antibody
Immunogen Synthesized peptide derived from human MSK2 around the phosphorylation site of T568.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 95 kDa
Database Links
Alternative Names Phospho-MSK2 (T568)
Ribosomal protein S6 kinase alpha-4 antibody
S6K-alpha-4 antibody
90 kDa ribosomal protein S6 kinase 4 antibody
Nuclear mitogen- and stress-activated protein kinase 2 antibody
Ribosomal protein kinase B antibody
RSKB antibody
MSK2 antibody
Function Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

You recently viewed

Clear recently viewed