Anti-Phospho-Neu (Y1221/Y1222) antibody

Rs. 50,211.00
SKU stj91025

General Information

Product name Anti-Phospho-Neu (Y1221/Y1222) antibody
Short Description
Description Rabbit polyclonal to Phospho-Neu (Y1221/Y1222).
Applications WB,IHC,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000
Protein Name Anti-Phospho-Neu (Y1221/Y1222) antibody
Immunogen Synthesized peptide derived from human Neu around the phosphorylation site of Y1221/Y1222.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat,Monkey
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


Gene ID
Gene Symbol
Molecular Weight 175 kDa
Database Links
Alternative Names Phospho-Neu (Y1221/Y1222)
Receptor tyrosine-protein kinase erbB-2 antibody
Metastatic lymph node gene 19 protein antibody
MLN 19 antibody
Proto-oncogene Neu antibody
Proto-oncogene c-ErbB-2 antibody
Tyrosine kinase-type cell surface receptor HER2 antibody
p185erbB2 antibody
CD antigen CD340 antibody
HER2 antibody
MLN19 antibody
NEU antibody
NGL antibody
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Cellular Localization Isoform 1: Cell membrane. Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.. Isoform 2: Cytoplasm. Nucleus.. Isoform 3: Cytoplasm. Nucleus.
Tissue Specificity Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
Swiss-Prot Key


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